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- <text id=93TT0729>
- <title>
- Dec. 13, 1993: DNA By Special Delivery
- </title>
- <history>
- TIME--The Weekly Newsmagazine--1993
- Dec. 13, 1993 The Big Three:Chrysler, Ford, and GM
- </history>
- <article>
- <source>Time Magazine</source>
- <hdr>
- MEDICINE, Page 58
- DNA By Special Delivery
- </hdr>
- <body>
- <p>While legions of scientists are hunting down mutant genes like
- the culprit that causes some colon cancers, other researchers
- are seeking ways to fix the damage done by these mistakes of
- nature. Still in its infancy, the field of "gene therapy" has
- spawned dozens of experiments aimed at treating ailments ranging
- from cystic fibrosis to brain tumors. The goal is to transplant
- new genes into humans to do the work of defective ones--or
- to give patients extra genes useful in fighting diseases.
- </p>
- <p> One of the toughest tricks is getting genes into the right spot
- in the body. Up to now, researchers have generally used benign
- viruses to carry the genetic material DNA into cells, but there
- are fears that the seemingly nonthreatening transport vehicles
- could sometimes cause viral infections. Last week scientists
- at the University of Michigan and the University of Pittsburgh
- reported in Proceedings of the National Academy of Sciences
- that they had succeeded in injecting DNA directly into human
- cells. Instead of riding a virus, the DNA was encased in liposomes,
- harmless little bubbles of fat.
- </p>
- <p> Led by Michigan's Dr. Gary Nabel, the researchers treated five
- patients with melanoma, a deadly skin cancer. The tumors were
- injected with the gene HLA-B7, which produces a protein that
- can help the immune system fight the cancer. In all five patients,
- the genes safely entered the tumor cells and began making protein,
- and in one case the tumors shrank. The technique is no miracle
- cure, but the experiment adds a promising new weapon to the
- arsenal of genetic medicine.
- </p>
-
- </body>
- </article>
- </text>
-
-